Association of thymidylate synthase enhancer region polymorphisms with thymidylate synthase activity in vivo
نویسندگان
چکیده
منابع مشابه
Thymidylate Synthase Inhibitors
Folate analogues that inhibit thymidylate synthase (TS) selectively were developed based on TS and folate molecular structures and properties. The structure-activity relationship, preclinical and clinical development, and issues of potential importance in the future success of these TS inhibitors are reviewed herein. Properties of these new compounds depend mainly on the use of the reduced fola...
متن کاملThymidylate Synthase Inhibitors
Folate analogues that inhibit thymidylate synthase (TS) selectively were developed based on TS and folate molecular structures and properties. The structure-activity relationship, preclinical and clinical development, and issues of potential importance in the future success of these TS inhibitors are reviewed herein. Properties of these new compounds depend mainly on the use of the reduced fola...
متن کاملThymidylate Synthase Inhibitors
Folate analogues that inhibit thymidylate synthase (TS) selectively were developed based on TS and folate molecular structures and properties. The structure-activity relationship, preclinical and clinical development, and issues of potential importance in the future success of these TS inhibitors are reviewed herein. Properties of these new compounds depend mainly on the use of the reduced fola...
متن کاملThymidylate Synthase Inhibitors
Folate analogues that inhibit thymidylate synthase (TS) selectively were developed based on TS and folate molecular structures and properties. The structure-activity relationship, preclinical and clinical development, and issues of potential importance in the future success of these TS inhibitors are reviewed herein. Properties of these new compounds depend mainly on the use of the reduced fola...
متن کاملThymidylate Synthase Inhibitors
Folate analogues that inhibit thymidylate synthase (TS) selectively were developed based on TS and folate molecular structures and properties. The structure-activity relationship, preclinical and clinical development, and issues of potential importance in the future success of these TS inhibitors are reviewed herein. Properties of these new compounds depend mainly on the use of the reduced fola...
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ژورنال
عنوان ژورنال: The Pharmacogenomics Journal
سال: 2010
ISSN: 1470-269X,1473-1150
DOI: 10.1038/tpj.2010.43